Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • At standard doses, coadministration of efavirenz and voriconazole is contraindicated[DHHS ART]
  • Etravirine and voriconazole concentrations increase during coadministration; thus, although no dose adjustment is currently necessary, caution is recommended in combining these drugs and therapeutic drug monitoring should be considered when they are coadministered[DHHS ART]
  • No data exist on the interaction between rilpivirine and voriconazole, but it is expected that plasma concentrations of rilpivirine will be increased; no dose adjustments are currently recommended[FDA Rilpivirine]

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