Indinavir concentrations and St John's wort.

Piscitelli SC, Burstein AH, Chaitt D, Alfaro RM, Falloon J.

Lancet. 2000 Feb 12;355(9203):547-8. doi: 10.1016/S0140-6736(99)05712-8.

St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.

PMID: 10683007

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.