Summary

Introduction

• Approved antiretrovirals have varying potential for drug–drug interactions with other antiretrovirals and with concomitant medications
• Comedication use is common in HIV-infected patients^{[Zhou 2014; Greene 2014; Robertson 2005]}
• Clinicians providing care to HIV-infected patients must be cognizant of the potential for drug–drug interactions

Potential Mechanisms of Antiretroviral Drug Interactions

Absorption, Distribution, Metabolism, and Elimination
• Antiretrovirals undergo pharmacokinetic transformation during absorption, distribution, metabolism, and elimination
• Most clinically relevant drug interactions involving antiretrovirals occur because of alterations in drug-metabolizing enzyme activity
• Renal elimination is not a common cause of antiretroviral drug interactions
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