Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)



  • Approved antiretrovirals have varying potential for drug–drug interactions with other antiretrovirals and with concomitant medications
  • Comedication use is common in HIV-infected patients[Zhou 2014; Greene 2014; Robertson 2005]
  • Clinicians providing care to HIV-infected patients must be cognizant of the potential for drug–drug interactions

Potential Mechanisms of Antiretroviral Drug Interactions

    Absorption, Distribution, Metabolism, and Elimination
    • Antiretrovirals undergo pharmacokinetic transformation during absorption, distribution, metabolism, and elimination
    • Most clinically relevant drug interactions involving antiretrovirals occur because of alterations in drug-metabolizing enzyme activity
    • Renal elimination is not a common cause of antiretroviral drug interactions
    • ...

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