- Approved antiretrovirals have varying potential for drug–drug interactions with other antiretrovirals and with concomitant medications
- Comedication use is common in HIV-infected patients[Zhou 2014; Greene 2014; Robertson 2005]
- Clinicians providing care to HIV-infected patients must be cognizant of the potential for drug–drug interactions
Potential Mechanisms of Antiretroviral Drug Interactions
Absorption, Distribution, Metabolism, and Elimination
- Antiretrovirals undergo pharmacokinetic transformation during absorption, distribution, metabolism, and elimination
- Most clinically relevant drug interactions involving antiretrovirals occur because of alterations in drug-metabolizing enzyme activity
- Renal elimination is not a common cause of antiretroviral drug interactions...