Management of Occupational and Nonoccupational HIV Exposure

  • Author: Christopher B. Hurt, MD (More Info)
  • Editors In Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/18 (What's New)


    History and Overview of Data Sources
    • Only clinical efficacy data available for PEP come from CDC’s case-control database of exposed healthcare workers and seroconverters[Cardo 1997; Do 2003]
    • Rationale for recommending PEP:
      • Administration of tenofovir DF–based PEP within first 24-36 hours of vaginal exposure in macaque model prevented infection[Otten 2000]
    Case-Control Data From Exposed and Seroconverted Healthcare Workers
      Time Window for Initiating Postexposure Prophylaxis
        Algorithm for Initiating Postexposure Prophylaxis

        Action required