Time required for HIV to traverse intact vaginal mucosa depends on multiple factors, including hormonal and microbiological environment at time of exposure[Pope 2003]
Data from macaque models identify 24-36 hours postexposure as ideal window to administer PEP[Black 1997; Tsai 1998; Otten 2000]
Prevention of mother-to-child transmission data show zidovudine administered intrapartum and within 48 hours postpartum reduces transmission by at least 50% compared with later treatments[Wade 1998]
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