Management of Occupational and Nonoccupational HIV Exposure

  • Author: Christopher B. Hurt, MD (More Info)
  • Editors In Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/18 (What's New)


  • USPHS and CDC nonoccupational PEP guidelines suggest following up with exposed patients after 72 hours to assess tolerance of prescribed PEP regimen and reiterate specific instructions that may have been missed during rapid assessment and initiation of treatment (Management Guidelines)[USPHS 2013]
    • CDC nonoccupational PEP guidelines similarly encourage early follow-up after a 28 –day course of PEP is prescribed (Management Guidelines)[CDC 2016]
      • May also consider giving starter pack (3-7 days) of PEP, although adherence is lower compared with 28-day supply[Ford 2015]

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