Management of Occupational and Nonoccupational HIV Exposure

  • Author: Christopher B. Hurt, MD (More Info)
  • Editors In Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/18 (What's New)



  • 2.1 million new HIV infections occurred worldwide in 2015[UNAIDS 2016]
  • Biomedical prevention/use of antiretroviral agents to prevent at-risk HIV-negative individuals from becoming newly infected important adjuvant to behavioral risk-reduction interventions
  • Strategies for biomedical prevention:
    • Treatment as prevention
    • Pre-exposure prophylaxis
    • Postexposure prophylaxis

Assessing Risk of HIV Transmission Following an Exposure

    Overview of Estimated Transmission Risks
    • Likelihood of HIV transmission related to exposure type and quantity of virus in inoculum
      • Potentially infectious materials include blood, bodily fluids, genital secretions, breast milk
      • Urine, feces, saliva, vomitus, nasal secretions, sputum, tears, sweat not considered infectious
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