Clinical Implications of HIV Pathogenesis

  • Author: David M. Margolis, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)


  • Natural course of HIV disease varies among infected individuals, influenced by viral and host factors[Buchbinder 1994; Markowitz 2005; Gottlieb 2007]
    • Viral factors include the virulence and tropism of the infecting strain(s) and infection with drug-resistant virus[Little 2002]
    • Host factors include those that modulate the immune response and factors that affect viral replication within host cells

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Keywords: Tropism