Clinical Implications of HIV Pathogenesis

  • Author: David M. Margolis, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)


  • Ultrasensitive HIV-1 RNA tests demonstrate that most patients on suppressive ART continue to exhibit low levels of viremia[Dornadula 1999; Palmer 2008]
  • However, evidence suggests that residual viremia is archival and nonevolving, implying that virologic failure should not occur if ART can be maintained[Shen 2008]
  • Most studies of ART intensification with additional antiretrovirals have shown no significant effect on residual viremia[Dinoso 2009; Gandhi 2010]

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