Clinical Implications of HIV Pathogenesis
Summary
- Ultrasensitive HIV-1 RNA tests demonstrate that most patients on suppressive ART continue to exhibit low levels of viremia[Dornadula 1999; Palmer 2008]
- However, evidence suggests that residual viremia is archival and nonevolving, implying that virologic failure should not occur if ART can be maintained[Shen 2008]
- Most studies of ART intensification with additional antiretrovirals have shown no significant effect on residual viremia[Dinoso 2009; Gandhi 2010]
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