Summary

Introduction

• The HIV pandemic continues to pose significant challenges for medicine, public health, and public policy
• Major advances are needed to prevent HIV transmission in at-risk populations worldwide
  • Progress is being made toward the development of a preventive vaccine^{[Rerks-Ngarm 2009; Haynes 2012; NIH HIV Vaccine]}
  • Use of ART for HIV prevention highly effective
• Eradication of HIV from infected patients remains an important goal, given the global burden of HIV disease and the challenges in implementing access to treatment and care
• Better understanding of HIV pathogenesis is critical to addressing these challenges

The Acute Phase of HIV Infection: Downstream Effects

• Viral replication and an inflammatory host response induce destruction of CD4+ cells early in acute HIV infection
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