The Approach to the HIV-Infected Patient With Specific Symptom Complexes/Common Presentations

  • Author: Steven C. Johnson, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

    Adverse Effects From Antiretroviral Therapy
    • Serious adverse events that may occur with use of ART include lactic acidosis, pancreatitis, hypersensitivity reactions, hepatotoxicity, increased risk of cardiovascular disease, insulin resistance and diabetes, hyperlipidemia, gastrointestinal adverse effects, renal insufficiency, and leukopenia and anemia (Management Guidelines)[DHHS Guidelines]
    Immune Reconstitution Inflammatory Syndrome
    • IRIS can occur with ART use in patients with active opportunistic infections[Shelbourne 2005]
    • IRIS leads to a paradoxical worsening of signs and symptoms of the opportunistic infection

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