Management of Sexually Transmitted Diseases in HIV-Infected Men and Women

  • Author: Jeanne Marrazzo, MD, MPH, FACP, FIDSA (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 2/8/18 (What's New)


  • Neurosyphilis can take several forms, including meningitis, cranial neuropathies, uveitis, retinitis, and gumma or vasculitis in the CNS
  • CDC STD Treatment Guidelines recommend CSF examination in HIV-infected patients with syphilis with specific findings (Table 2)
    • CSF abnormalities are most likely in patients with CD4+ cell count ≤ 350 cells/mm3 and/or a serum rapid plasma reagin titer ≥ 1:32 (Management Guidelines)[CDC STD]

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