Viral Infections

  • Author: Jin S. Suh, MD, FACP; Humberto R. Jimenez, PharmD, BCPS, AAHIVP (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/21 (What's New)


  • HSV DNA detection with PCR assays is the preferred modality of HSV-2 diagnosis, although viral culture remains important to identify acyclovir resistance
  • Serologic testing can be used to diagnose HSV if recurrent genital symptoms are continually negative by PCR or culture, clinical signs of HSV infection are present, or when a partner has documented HSV infection[CDC STI] (Management Guidelines)
  • Routine serologic screening for HSV-2 may be considered as a part of HIV management (Management Guidelines)[CDC OI]

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