Although PML incidence has decreased significantly since the widespread use of ART, PML has been reported in HIV-infected patients with CD4+ cell counts > 300 cells/mm3 and as a complication of IRIS[Albrecht 1998; Ratnam 2006]
Clinical Presentation
Clinical manifestations of PML vary depending on the area of the central nervous system involved, ranging from diffuse encephalopathy to focal deficits such as ataxia, hemiparesis, or speech difficulties
