Viral Infections

  • Author: Jin S. Suh, MD, FACP; Humberto R. Jimenez, PharmD, BCPS, AAHIVP (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/21 (What's New)


  • Although PML incidence has decreased significantly since the widespread use of ART, PML has been reported in patients with HIV who have CD4+ cell counts > 300 cells/mm3 and as a complication of IRIS[Albrecht 1998]
  • Diagnosis of PML-IRIS should be considered in any person with HIV developing unexplained neurologic disorders or worsening of a previously diagnosed after the initiation or resumption of ART

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