Viral Infections
Summary
- Presumptive diagnosis of progressive multifocal leukoencephalopathy (PML) can be achieved via MRI, which almost always demonstrates distinct white matter lesions in areas of the brain corresponding to the clinical deficits
- Polymerase chain reaction detection of the JC virus in cerebrospinal fluid can be used to confirm diagnosis
- Definitive diagnosis of PML is made by brain biopsy, which shows characteristic focal myelin loss with bizarre astrocytes and lipid-laden macrophages
Action required
- Login now to access all of your entitled content
or - View additional options to gain access to this content