Viral Infections

  • Author: Jin S. Suh, MD, FACP; Humberto R. Jimenez, PharmD, BCPS, AAHIVP (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/21 (What's New)



  • Incidence of nearly all AIDS-defining opportunistic infections, including viral infections, has decreased significantly since the introduction of potent ART[Murphy 2004; Suh 2006]
  • Viral infections remain an important cause of morbidity and mortality in patients with HIV (Table 1)
    • These occur most notably in individuals who are unaware that they are HIV infected, who cannot tolerate ART or adhere to it poorly, or who have poor access to adequate healthcare

Herpes Simplex Virus

    • HSV-1 and HSV-2 commonly cause disease in persons with HIV
      • HSV-1 is normally acquired early in life
      • HSV-2 is usually acquired through sexual contact
      • Seroprevalence rates near 70% for HSV-2 have been reported in the population of persons with HIV
        • Including 95% of men who have sex with men who have been diagnosed with an AIDS-defining event
    Clinical Presentation