Viral Infections

  • Author: Jin S. Suh, MD, FACP (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/26/16 (What's New)



  • Incidence of nearly all AIDS-defining opportunistic infections, including viral infections, has decreased significantly since the introduction of potent ART[Murphy 2004; Suh 2006]
  • Viral infections remain an important cause of morbidity and mortality in HIV-infected patients (Table 1)
    • These occur most notably in individuals who are unaware that they are HIV-infected, who cannot tolerate ART or adhere to it poorly, or who have poor access to adequate healthcare

Herpes Simplex Virus

    • HSV-1 and HSV-2 commonly cause disease in HIV-infected persons
      • HSV-1 is normally acquired early in life
      • HSV-2 is usually acquired through sexual contact
      • Seroprevalence rates near 70% for HSV-2 have been reported in the HIV-infected population
    Clinical Presentation