Incidence of nearly all AIDS-defining opportunistic infections, including viral infections, has decreased significantly since the introduction of potent ART[Murphy 2004; Suh 2006]
Viral infections remain an important cause of morbidity and mortality in patients with HIV (Table 1)
These occur most notably in individuals who are unaware that they are HIV infected, who cannot tolerate ART or adhere to it poorly, or who have poor access to adequate healthcare
Herpes Simplex Virus
Epidemiology
HSV-1 and HSV-2 commonly cause disease in persons with HIV
HSV-1 is normally acquired early in life
HSV-2 is usually acquired through sexual contact
Seroprevalence rates near 70% for HSV-2 have been reported in the population of persons with HIV
Including 95% of men who have sex with men who have been diagnosed with an AIDS-defining event
Clinical Presentation
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