- Incidence of HIV-associated fungal infections has decreased significantly with the advent of effective ART[Palella 2006]
- Certain fungal infections (eg, oropharyngeal candidiasis) remain sentinel signs of HIV infection and should prompt HIV testing in people at risk
- In patients living with HIV, fungal infections indicate disease progression and the need to initiate or review ART
Like other opportunistic infections, HIV-associated fungal infections have decreased significantly in incidence with the advent of effective antiretroviral therapy.[Palella 2006] However, certain fungal infections, such as oropharyngeal candidiasis, remain sentinel signs of HIV infection, and the appearance of oropharyngeal candidiasis in a person at risk of HIV infection should prompt HIV testing. In a person living with HIV, the development of a fungal infection suggests disease progression and immune dysfunction and should prompt consideration of new or altered antiretroviral therapy.
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