Fungal Infections

  • Author: William G. Powderly, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/18/19 (What's New)


  • Histoplasmosis is caused by a fungus endemic in the Mississippi and Ohio River valleys of North America and in parts of Central and South America and the Caribbean
  • Primary infection or reactivation disease can occur in persons with HIV living in, visiting or previously resident in endemic areas
  • Disseminated histoplasmosis usually occurs in people with CD4+ cell counts < 150 cells/mm3[Wheat 1990]

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