inPractice® - Kaposi’s Sarcoma Treatment

Management of AIDS-Defining Cancers

Authors: David Aboulafia, MD (More Info)
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 4/9/18 (What's New)

Summary

KS treatment is individualized according to prognosis and the goal of therapy
Indications for systemic chemotherapy include widespread skin involvement, extensive oral KS, marked symptomatic edema, rapidly progressive disease, symptomatic visceral KS, and KS flare

Local Therapy

Localized KS lesions may be managed by surgery, intralesional chemotherapy,^{[Boudreaux 1993; Brambilla 2010]} external beam radiation (Management Guidelines),^{[BHIVA HIV Cancer; Le Bourgeois 1994; Kigula-Mugambe 2005; Kirova 1998; Swift 1996; Gressen 1999]} and alitretinoin topical gel (9-cis-retinoic acid) (Management Guidelines)^{[FDA Alitretinoin; NCCN KS]}

Antiretroviral Therapy

Systemic Chemotherapy

Liposomal Anthracyclines

Taxanes

Salvage Therapy

Investigational Therapies

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Keywords: Cancer