inPractice® - Systemic Chemotherapy

Management of AIDS-Defining Cancers

Authors: David Aboulafia, MD (More Info)
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 4/9/18 (What's New)

Summary

Liposomal anthracyclines and taxanes are the major chemotherapeutic agents used to treat KS (Management Guidelines)^{[NCCN KS]}
G-CSFs (eg, pegfilgrastim) are useful adjuncts to chemotherapy in patients with an ANC < 1000 cells/mm³

Liposomal Anthracyclines

Liposomal anthracycline pegylated doxorubicin liposomal is used as first-line treatment for KS, typically in addition to ART (Management Guidelines)^{[NCCN KS; Krown 2004b; Northfelt 1998; Northfelt 1997; Cianfrocca 2010]}

Taxanes

Salvage Therapy

Investigational Therapies

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Keywords: Cancer