Non–AIDS-Defining Cancers

  • Authors: David Aboulafia, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/15/21 (What's New)


  • Individuals with HIV have increased incidence of several cutaneous cancers, including SCC, BCC, melanoma, and Merkel cell carcinoma (Figure 11)[Smith 1993; Engels 2002; Wilkins 2006; Crum-Cianflone 2009]
    • Persons with HIV also at risk of HPV–associated genital in situ and invasive SCC
  • HIV-infected patients with skin cancer appear to be younger, have multiple tumors arising even in non–sun-exposed areas, may present with aggressive skin carcinomas, have increased rate of recurrence, more frequently exhibit treatment-associated complications, and seem to have poorer outcome[Pantanowitz 2006]

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Keywords: Cancer