Management of Hematologic Disorders

  • Author: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Introduction

  • The untreated natural history of HIV infection is associated with a relatively high prevalence of anemia, neutropenia, and thrombocytopenia
  • Cytopenias hinder therapy directed at HIV, the opportunistic infections and neoplasms of AIDS, may increase the risk of bacterial infection, and impact quality of life

Hematologic abnormalities were identified early in the HIV epidemic.[Zon 1988; Mitsuyasu 1993; Moses 1998] The most commonly observed hematologic complications associated with HIV infection are cytopenias. The untreated natural history of HIV infection is associated with a relatively high prevalence of anemia, neutropenia, and thrombocytopenia. The prevalence of each of these cytopenias tends to increase as HIV infection progresses from asymptomatic infection to advanced disease and AIDS.[...

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