Management of Hematologic Disorders

  • Author: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


    Epidemiology, Clinical Presentation, and Etiology
    • 35% of ART-treated patients in the US have been reported to be anemic[Mildvan 2007]
    • Anemia in untreated patients reported to range from 1% to 10% in asymptomatic HIV, 10% to 25% with CD4+ cell count–defined AIDS, and 30% to 60% with AIDS-defining illness[Sullivan 1998]
    Clinical Presentation
    • Clinical manifestations of anemia vary as hemoglobin levels decrease but are similar to those in HIV-uninfected individuals (Table 1)
      Laboratory Diagnosis
        Treatment of Anemia
          Thresholds for Treatment
            Antiretroviral Therapy
              Nutrient Replacement
                Hematopoietic Growth Factors
                  Red Blood Cell Transfusion

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