Management of Hematologic Disorders

  • Author: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

    Epidemiology
    • Thrombocytopenia can occur independently of other cytopenias and at all stages of HIV infection[Evatt 2005; Pechère 1993; Miguez-Burbano 2005]
    • 1-year incidence of significant thrombocytopenia in United States ranges from 1.7% with asymptomatic HIV to 3.1% with CD4+ cell count–defined AIDS and 8.7% with AIDS-defining illness[Sullivan 1997; Vannappagari 2011]
    • Risk of thrombocytopenia is increased by multiple patient-, virus-, and drug-related factors[Marks 2009]
    Clinical Presentation
      Etiology
        Treatment
          Antiretroviral Therapy
            Corticosteroids and Immunoglobulin Therapy
              Anti-Rh Antibody
                Splenectomy
                  Alternative Therapies

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