Management of Hematologic Disorders

  • Author: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

  • Coagulation abnormalities are less frequent in patients with HIV infection most commonly manifesting as lupus anticoagulant[Cohen 1986; Gold 1986; Bloom 1986; Cohen 1989] and may also result from lower free protein S levels in HIV-infected patients[Stahl 1993; Bissuel 1992]
  • Clinical data indicate incidence of thrombotic disease is increased in HIV-infected individuals, with thrombosis occurring at a rate of 2.6/1000 person-years[Sullivan 2000]
  • Risk factors for thrombotic disease in HIV-infected individuals may include older age, race, concomitant AIDS-defining and other infections, hospitalization, and some therapeutic agents[Sullivan 2000; Ahonkhai 2008]

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