Hepatic Disease in HIV-Infected Patients

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)

Introduction to Hepatic Disease

  • Abnormal liver test results are seen in approximately 30% of HIV-infected patients[Crum-Cianflone 2010]
  • HIV-infected patients diagnosed with potential causes of liver disease (Table 1) or exhibiting clinical signs of liver disease (Table 2) should undergo a comprehensive medical evaluation

Liver disease ranks as a serious cause of morbidity and mortality in HIV-infected persons whose HIV disease is effectively controlled with antiretroviral therapy.[Weber 2006] Abnormal liver test results are seen in nearly 30% of HIV-infected patients.[Crum-Cianflone 2010] Chronic infection with hepatitis C virus (HCV) or hepatitis B virus (HBV) represents the most significant cause of liver disease in HIV-infected persons (Table 1). The shared routes of transmission of HIV, HCV, and HBV help to explain this phenomenon.[...

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