Hepatic Disease in Patients With HIV

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/13/21 (What's New)

Summary

  • Treatment of HIV disease may ameliorate the development of chronic liver disease due to viral hepatitis[Shafran 2007]
  • Incidence
    • In randomized, controlled trials, the proportion of patients receiving combination ART who have grades 3 or 4 elevations in serum ALT or AST levels range from approximately 2% to 18%[Nuñez 2006]
    • Ritonavir-boosted PIs have not been associated with higher rates of hepatotoxicity
    Pathogenesis
      Immune reconstitution
        Direct Toxicity and/or Drug Metabolism
          Idiosyncratic Hypersensitivity Reactions
          Symptoms and Diagnosis
            Treatment of Drug-Induced Liver Disease

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