Hepatic Disease in HIV-Infected Patients

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)

Summary

  • Pathogenesis of antiretroviral-induced liver injury is not known
    • Mitochondrial Toxicity
    • Inhibition of mitochondrial DNA synthesis leading to mitochondrial toxicity varies by specific NRTI
    Immune reconstitution
    • Based on HBV/HIV coinfection studies, increases in liver enzymes may result from increasing immune response to a viral pathogen when seroconversion has been reported in the setting of ART[Piroth 2000]
    Direct Toxicity and/or Drug Metabolism
      Idiosyncratic Hypersensitivity Reactions

      Action required

      Keywords: Drug-Drug Interactions, Hepatic Complications, Special Populations

      ©2020 Clinical Care Options, LLC. All Rights Reserved.

      The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.