Hepatic Disease in HIV-Infected Patients

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)

Summary

  • Pathogenesis of antiretroviral-induced liver injury is not known
  • Mitochondrial Toxicity
    • Inhibition of mitochondrial DNA synthesis leading to mitochondrial toxicity varies by specific NRTI
    Immune reconstitution
    • Based on HBV/HIV coinfection studies, increases in liver enzymes may result from increasing immune response to a viral pathogen when seroconversion has been reported in the setting of ART[Piroth 2000]
    Direct Toxicity and/or Drug Metabolism
      Idiosyncratic Hypersensitivity Reactions

      Action required