Hepatic Disease in HIV-Infected Patients
Summary
- Pathogenesis of antiretroviral-induced liver injury is not known Mitochondrial Toxicity
- Inhibition of mitochondrial DNA synthesis leading to mitochondrial toxicity varies by specific NRTI
- Based on HBV/HIV coinfection studies, increases in liver enzymes may result from increasing immune response to a viral pathogen when seroconversion has been reported in the setting of ART[Piroth 2000]
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