Hepatic Disease in Patients With HIV

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/13/21 (What's New)


  • Pathogenesis of antiretroviral-induced liver injury is not known
  • Immune reconstitution
    • Based on coinfection studies of persons with HIV and HBV coinfection, increases in liver enzymes may result from increasing immune response to a viral pathogen when seroconversion has been reported in the setting of ART[Piroth 2000]
    • Evidence for the occurrence of immune-related flares from chronic HCV infection is less certain
    Direct Toxicity and/or Drug Metabolism
      Idiosyncratic Hypersensitivity Reactions

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