Hepatic Disease in HIV-Infected Patients

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)

Summary

    Epidemiology and Mortality
    • Worldwide, chronic HBV infection affects approximately 7% to 15% of HIV-infected persons[Kourtis 2012; Zhou 2007]
    • In coinfected individuals, liver-related mortality (Figure) was highest in subjects with lower nadir CD4+ cell counts and twice as high after 1996, when potent ART was introduced
    Natural History and Diagnosis
    • HBV is identified by the presence of specific HBV antigens, HBV DNA, and anti-HBV antibodies (Table 3)
    Hepatitis B Vaccination

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