Hepatic Disease in HIV-Infected Patients

  • Author: Mark S. Sulkowski, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)


  • HIV infection can accelerate progression of HBV-related liver disease
  • US guidelines recommend initiating ART that includes 2 agents active against HBV in all HBV/HIV-coinfected patients regardless of CD4+ cell count or HBV disease status (Management Guidelines)[DHHS ART]
  • Patients Refusing or Unable to Tolerate HIV Therapy or Who Are HIV Long-term Nonprogressors
      Patients Who Cannot Receive Tenofovir Disoproxil Fumarate or Tenofovir Alafenamide
        Patients Who Have Drug-Resistant HBV

        Action required