Endocrine Disorders: Evaluation and Management

  • Author: Todd T. Brown, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 11/14/16 (What's New)


  • Metformin is considered first-line therapy for a newly diagnosed patient who does not have a contraindication to the drug
  • Gastrointestinal adverse effects can be minimized by starting at a low dose and increasing slowly[FDA Metformin]
  • Metformin is contraindicated in patients with renal insufficiency (a serum creatinine level > 1.5 mg/dL for men and > 1.4 mg/dL for women), hepatic failure, congestive heart failure, or alcoholism

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