Endocrine Disorders: Evaluation and Management
Summary
- Metformin is considered first-line therapy for a newly diagnosed patient who does not have a contraindication to the drug
- Gastrointestinal adverse effects can be minimized by starting at a low dose and increasing slowly[FDA Metformin]
- Metformin is contraindicated in patients with renal insufficiency (a serum creatinine level > 1.5 mg/dL for men and > 1.4 mg/dL for women), hepatic failure, congestive heart failure, or alcoholism
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