Endocrine Disorders: Evaluation and Management

  • Author: Todd T. Brown, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 11/14/16 (What's New)


  • In patients with a normal sleep/wake cycle, laboratory assessment of hypogonadism should take place between 8:00 and 10:00 am (Management Guidelines)[Testosterone Guidelines]
  • In HIV-infected men, especially those with chronic hepatitis, measurement of free testosterone is recommended, either by the equilibrium dialysis method or calculated using the total testosterone measured by liquid chromatography/tandem mass spectrometry, sex hormone binding globulin, and serum albumin[Mylonakis 2001; Vermeulen 1999]
  • For total testosterone, a morning testosterone < 300 ng/dL is considered hypogonadal[Testosterone Guidelines]

Action required