Endocrine Disorders: Evaluation and Management

  • Author: Todd T. Brown, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 11/14/16 (What's New)

Summary

  • TSH assays with a limit of detection of < 0.02 mU/L are used to identify most cases of hypothyroidism and hyperthyroidism[Dayan 2001]
  • Current guidelines recommend obtaining measurements of free T4 as well as TSH in rare circumstances, such as when pituitary or hypothalamic disease is suspected (Management Guidelines)[Thyroid Dysfunction Guidelines]
    • Abnormal T4 aids in diagnosis of primary hypothyroidism, in which TSH is also elevated, and central hypothyroidism or thyroid hormone resistance, where TSH levels are normal or low

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