Management of Neurologic Diseases

  • Authors: David M. Simpson, MD; Jessica Robinson-Papp, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Cerebral mass lesions are usually treated presumptively as cerebral toxoplasmosis in patients with CD4+ cell counts < 200 cells/mm3 and positive serum toxoplasmosis antibodies
  • Response to appropriate antimicrobial therapy is diagnostic, eg, pyrimethamine and sulfadiazine (with leucovorin supplementation)
  • Failure to respond to treatment, typically by 2 weeks after initiation, is an indication for further diagnostic study

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