Ocular Complications Associated With HIV Infection
Summary
- In the pre-HAART era, CMV retinitis affected approximately 30% of patients with AIDS[Hoover 1996]
- Historically, treatment with foscarnet and ganciclovir provided limited efficacy, with frequent recurrence, requiring lifelong maintenance therapy[Foscarnet Trial 1994]
- Relapse may be due to subtherapeutic intraocular drug levels or to drug resistance[Kuppermann 1993; Arevalo 1995; Jabs 1998a; Jabs 1998b; Weinberg 2003]
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