Antidepressant therapy can improve adherence to antiretroviral regimens among HIV-infected and depressed patients.

Dalessandro M, Conti CM, Gambi F, Falasca K, Doyle R, Conti P, Caciagli F, Fulcheri M, Vecchiet J.

J Clin Psychopharmacol. 2007 Feb;27(1):58-61. doi: 10.1097/JCP.0b013e31802f0dd1.

Several strategies have been introduced to manage nonadherence to highly active antiretroviral therapy (HAART). Treatment with antidepressants may improve self-reported adherence. In this brief report, a small sample of HIV-depressed patients (n = 9) were treated for a 6-month period with antidepressants improving self-reported adherence based on the HAART scale (poor, good, satisfactory, and optimal). Before the antidepressant treatment, adherence was reported as "good" by 3 patients and "satisfactory" by 6 patients. After antidepressant therapy, adherence to antiretroviral regimes was statistically higher in HIV-depressed on treatment than in HIV-depressed patients not treated with antidepressants (P < 0.0001). We used chi2 test with a significance level at P < 0.05. Treating depression in HIV-infected patients may serve to improve adherence to HAART.

PMID: 17224714

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.