Neuropsychological and neurological manifestations of HIV-1 dementia in drug users.

Handelsman L, Aronson M, Maurer G, Wiener J, Jacobson J, Bernstein D, Ness R, Herman S, Losonczy M, Song IS, et al..

J Neuropsychiatry Clin Neurosci. 1992 Winter;4(1):21-8. doi: 10.1176/jnp.4.1.21.

The cognitive and motor deficits associated with human immunodeficiency virus-1 (HIV-1) infection have been studied using neurological examination and neuropsychological tests. However, drug users with HIV-1 infection generally have been excluded from such studies. Forty-four well-characterized drug users stratified by Centers for Disease Control staging were administered a standardized neurological examination and a battery of neuropsychological tests under single-blind conditions designed to minimize the acute effects of psychoactive substances. The results of the blind neurological examination were consistent with the previously ascertained clinical staging of HIV-1 infection. The pattern of neuropsychological deficits across HIV-1 states was similar to those found in cohorts of homosexual men.

PMID: 1627958

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.