Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • In patients with suspected paradoxical IRIS, clinicians should exclude a worsening of the preexisting infection because of poor treatment adherence or drug resistance
  • Diagnosis of unmasking IRIS generally requires microbiologic confirmation
  • Virologic and immunologic response to ART should be confirmed before IRIS is diagnosed

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Keywords: IRIS