Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

  • Initiation of ART before the development of advanced immunosuppression is the most effective method of preventing IRIS
  • Patients initiating ART should be evaluated for infection, particularly individuals from areas with high prevalence for TB and cryptococcus
  • All patients with CD4+ cell counts < 100 cells/mm3 should undergo serum cryptococcal antigen screening
    • Screening
      Fluconazole Prophylaxis
        Corticosteroids/Antiinflammatories
          Timing of Antiretroviral Therapy

          Action required

          Keywords: Cryptococcus, IRIS, Resource-Limited Settings, Tuberculosis

          ©2020 Clinical Care Options, LLC. All Rights Reserved.

          The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.