Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

  • Initiation of ART before the development of advanced immunosuppression is the most effective method of preventing IRIS
  • Patients initiating ART should be evaluated for infection, particularly individuals from areas with high prevalence for TB and cryptococcus
  • All patients with CD4+ cell counts < 100 cells/mm3 should undergo serum cryptococcal antigen screening
    • Screening
      Fluconazole Prophylaxis
        Corticosteroids/Antiinflammatories
          Timing of Antiretroviral Therapy

          Action required

          Keywords: Cryptococcus, IRIS, Resource-Limited Settings, Tuberculosis

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