Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Pre-ART screening using a tuberculin skin test, a chest x-ray, and sputum acid-fast bacilli smears and cultures may be useful when evaluating patients from areas with high TB transmission rates, although ART should not be delayed if clinically indicated
  • Screening for cryptococcal antigen should be performed before ART initiation in patients with advanced immunosuppression from areas with high prevalence of cryptococcus

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