Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole.

Bicanic T, Meintjes G, Wood R, Hayes M, Rebe K, Bekker LG, Harrison T.

Clin Infect Dis. 2007 Jul 1;45(1):76-80. doi: 10.1086/518607. Epub 2007 May 25.

In a prospective observational study of 54 patients with human immunodeficiency virus-associated cryptococcal meningitis, the early fungicidal activity of amphotericin B (1 mg/kg/day) was significantly greater than that of fluconazole (400 mg/day). Compared with antiretroviral therapy-naive patients, patients developing cryptococcal meningitis while already receiving antiretroviral therapy had lower baseline fungal burdens and a longer median duration of survival, but there were no differences observed in fungal clearance, cerebrospinal fluid proinflammatory cytokines, or 10-week mortality.

PMID: 17554704

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.