Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study.

Sungkanuparph S, Filler SG, Chetchotisakd P, Pappas PG, Nolen TL, Manosuthi W, Anekthananon T, Morris MI, Supparatpinyo K, Kopetskie H, Kendrick AS, Johnson PC, Sobel JD, Larsen RA.

Clin Infect Dis. 2009 Sep 15;49(6):931-4. doi: 10.1086/605497.

A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.

PMID: 19681708

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.