Show Eula
Introduction
- An estimated 1.7 million children are living with HIV infection worldwide[UNAIDS]
- Mother-to-child HIV transmission is rare in well-resourced settings but more common in resource-limited countries
- Pediatric HIV infection is characterized by:
- Distinct clinical and virologic manifestations of perinatal HIV infection in growing, immunologically immature persons
- In utero, intrapartum, and/or postpartum neonatal exposure to ART
- The need for HIV virologic tests instead of antibody tests to diagnose perinatal HIV infection in infants younger than 18 months of age
- Age-specific differences in CD4+ cell counts
- Age-specific changes in drug metabolism and clearance
- Issues associated with ART adherence in infants and young children
Management of the HIV-Exposed Newborn
- Improved management of HIV in pregnancy has dramatically reduced the incidence of perinatally acquired HIV infection[Mandelbrot 1998; ...