Special Considerations in the Management of HIV-Infected Patients From Minority Communities

  • Authors: Bisola Ojikutu, MD, MPH; Valerie E. Stone, MD, MPH (More Info)
  • Section Editor: Judith S. Currier, MD, MSc
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/9/18 (What's New)

Summary

  • A subanalysis of ACTG 5095 found that a genetic polymorphism in the CYP2B6 gene associated with higher plasma efavirenz concentrations and increased central nervous system toxicity occurred more frequently in blacks than in whites[Haas 2004]
  • Early adverse events may have contributed to reduced adherence in black patients

Action required

Keywords: Initial Antiretroviral Therapy, Minority-Ethnic Communities, Pharmacokinetics, Special Populations

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