Special Considerations in the Management of HIV-Infected Patients From Minority Communities
Summary
- A subanalysis of ACTG 5095 found that a genetic polymorphism in the CYP2B6 gene associated with higher plasma efavirenz concentrations and increased central nervous system toxicity occurred more frequently in blacks than in whites[Haas 2004]
- Early adverse events may have contributed to reduced adherence in black patients
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