Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder

  • Author: Frederick L. Altice, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 2/5/20 (What's New)


  • Cocaine is a water-soluble hydrochloride salt that is either injected or taken by nasal inhalation
  • Cocaine hydrochloride may be converted to a free-base (“crack”) cocaine, which can be smoked
  • Cocaine’s half-life is short, resulting in the need for frequent administration

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