Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder

  • Author: Frederick L. Altice, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 2/5/20 (What's New)


  • Poppers are alkyl, butyl, or amyl nitrites/nitrates that when inhaled, cause vasodilation, euphoria, and lightheadedness accompanied by tachycardia and hypotension
  • Poppers are frequently used by MSM in a party setting to enhance sexual experience[Colfax 2006]
  • Poppers can lead to cardiovascular collapse when administered with another vasodilator such as a PDE inhibitor[Kloner 2005] and may cause allergic reactions, methemoglobinemia, and hemolytic anemia[Mattison 2001; Romanelli 2004]

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