Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder

  • Author: Frederick L. Altice, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 2/5/20 (What's New)


  • Disulfiram causes accumulation of acetaldehyde upon alcohol consumption, leading to painful symptoms such as facial flushing, dyspnea, nausea, vomiting, and headache
  • Disulfiram is not recommended as first-line pharmacotherapy for prevention of alcohol relapse but may be useful in conjunction with other interventions[Garbutt 2009]
  • Disulfiram should be provided only as directly administered therapy

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