inPractice® - NRTIs

Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder

Author: Frederick L. Altice, MD (More Info)
Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
Last Reviewed: 2/5/20 (What's New)

Summary

Currently approved NRTIs do not precipitate opioid withdrawal
Methadone affects the pharmacokinetics of several NRTIs (Table 6),^{[Bruce 2006a; Bruce 2013a]} including zidovudine^{[Rainey 2002]} and stavudine^{[Rainey 2000]}
Interactions between buprenorphine and NRTIs are not clinically significant^{[McCance-Katz 2001; Baker 2010]}

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Keywords: Drug-Drug Interactions, Initial Antiretroviral Therapy, IV Drug Use, Pharmacokinetics, Special Populations