Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder
Summary
- Currently approved NRTIs do not precipitate opioid withdrawal
- Methadone affects the pharmacokinetics of several NRTIs (Table 6),[Bruce 2006a; Bruce 2013a] including zidovudine[Rainey 2002] and stavudine[Rainey 2000]
- Interactions between buprenorphine and NRTIs are not clinically significant[McCance-Katz 2001; Baker 2010]
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