inPractice® - Tipranavir

Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder

Author: Frederick L. Altice, MD (More Info)
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 2/5/20 (What's New)

Summary

Standard dosing of tipranavir/ritonavir 500/200 mg twice daily may result in a decrease in methadone levels requiring an increase in methadone dose^{[FDA Tipranavir]}
Buprenorphine levels are not significantly decreased with tipranavir/ritonavir 500/200 mg twice daily^{[Bruce 2009a]}

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Keywords: Drug-Drug Interactions, Initial Antiretroviral Therapy, IV Drug Use, Pharmacokinetics, Special Populations